Crystal structure of human carbonic anhydrase II complexed with ananti-convulsant sugar sulphamate
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چکیده
منابع مشابه
Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.
The fructose-based sugar sulphamate RWJ-37497, a potent analogue of the widely used anti-epileptic drug topiramate, possesses anti-convulsant and carbonic anhydrase-inhibitory activities. We have studied the binding interactions of RWJ-37497 in the active site of human carbonic anhydrase II by X-ray crystallography. The atomic positions of the enzyme inhibitor complex were refined at a resoluti...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2002
ISSN: 0264-6021
DOI: 10.1042/0264-6021:3610437